Performance comparison of ventricular and arterial dP/dt max for assessing left ventricular systolic function during different experimental loading and contractile conditions
Maximal left ventricular (LV) pressure rise (LV dP/dt ), a classical marker of LV systolic function, requires LV catheterization, thus surrogate arterial pressure waveform measures have been proposed. We compared LV and arterial (femoral and radial) dP/dt to the slope of the LV end-systolic pressure...
Saved in:
Published in | Critical care (London, England) Vol. 22; no. 1; p. 325 |
---|---|
Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
England
29.11.2018
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | Maximal left ventricular (LV) pressure rise (LV dP/dt
), a classical marker of LV systolic function, requires LV catheterization, thus surrogate arterial pressure waveform measures have been proposed. We compared LV and arterial (femoral and radial) dP/dt
to the slope of the LV end-systolic pressure-volume relationship (Ees), a load-independent measure of LV contractility, to determine the interactions between dP/dt
and Ees as loading and LV contractility varied.
We measured LV pressure-volume data using a conductance catheter and femoral and radial arterial pressures using a fluid-filled catheter in 10 anesthetized pigs. Ees was calculated as the slope of the end-systolic pressure-volume relationship during a transient inferior vena cava occlusion. Afterload was assessed by the effective arterial elastance. The experimental protocol consisted of sequentially changing afterload (phenylephrine/nitroprusside), preload (bleeding/fluid bolus), and contractility (esmolol/dobutamine). A linear-mixed analysis was used to assess the contribution of cardiac (Ees, end-diastolic volume, effective arterial elastance, heart rate, preload-dependency) and arterial factors (total vascular resistance and arterial compliance) to LV and arterial dP/dt
.
Both LV and arterial dP/dt
allowed the tracking of Ees changes, especially during afterload and contractility changes, although arterial dP/dt
was lower compared to LV dP/dt
(bias 732 ± 539 mmHg⋅s
for femoral dP/dt
, and 625 ± 501 mmHg⋅s
for radial dP/dt
). Changes in cardiac contractility (Ees) were the main determinant of LV and arterial dP/dt
changes.
Although arterial dP/dt
is a complex function of central and peripheral arterial factors, radial and particularly femoral dP/dt
allowed reasonably good tracking of LV contractility changes as loading and inotropic conditions varied. |
---|---|
ISSN: | 1466-609X |