Injectable hydrogel encapsulating Cu 2 MnS 2 nanoplates for photothermal therapy against breast cancer

In order to explore the possibility of treating breast cancer by local photo-therapy, a photothermal agents loaded in situ hydrogel was established. In detail, The Cu MnS nanoplates were prepared by one-pot synthesis and, the thermosensitive Pluronic F127 was used as the hydrogel matrix. The Cu MnS...

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Published inJournal of nanobiotechnology Vol. 16; no. 1; p. 83
Main Authors Fu, Ji-Jun, Chen, Ming-Yue, Li, Jie-Xia, Zhou, Jun-Hua, Xie, Sheng-Nan, Yuan, Ping, Tang, Bo, Liu, Cheng-Cheng
Format Journal Article
LanguageEnglish
Published England 27.10.2018
Subjects
Animals
Cell Line, Tumor
Copper - chemistry
Female
Hydrogels - chemistry
Hyperthermia, Induced
Injections
Mammary Neoplasms, Animal - pathology
Mammary Neoplasms, Animal - therapy
Manganese - chemistry
Mice, Inbred BALB C
Nanoparticles - chemistry
Nanoparticles - ultrastructure
Phototherapy
Poloxamer - chemistry
Sulfides - chemistry
Injectable
Nanoplates
In-situ
Thermosensitive
Hydrogel
Cu2MnS2
Photothermal
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Summary:In order to explore the possibility of treating breast cancer by local photo-therapy, a photothermal agents loaded in situ hydrogel was established. In detail, The Cu MnS nanoplates were prepared by one-pot synthesis and, the thermosensitive Pluronic F127 was used as the hydrogel matrix. The Cu MnS nanoplates and the hydrogel were characterized by morphous, particle size, serum stability, photothermal performance upon repeated 808 nm laser irradiation as well as the rheology features. The therapeutic effects of the Cu MnS nanoplates and the hydrogel were evaluated qualitatively and quantitatively in 4T1 mouse breast cancer cells. The retention, photothermal efficacy, therapeutic effects and systemic toxicity of the hydrogel were assessed in tumor bearing mouse model. The Cu MnS nanoplates with a diameter of about 35 nm exhibited satisfying serum stability, photo-heat conversion ability and repeated laser exposure stability. The hydrogel encapsulation did not negatively influence the above features of the photothermal agent. The nanoplates loaded in situ hydrogel shows a phase transition at body temperature and, as a result, a long retention in vivo. The photothermal agent embedded hydrogel played a promising photothermal therapeutic effects in tumor bearing mouse model with low systemic toxicity after peritumoral administration.
ISSN:1477-3155