Effect of Coenzyme Q 10 on Insulin Resistance in Korean Patients with Prediabetes: A Pilot Single-Center, Randomized, Double-Blind, Placebo-Controlled Study

This study aimed to examine whether administration of coenzyme Q10, an antioxidant, improves insulin resistance in patients with prediabetes. The study design was a pilot single-center, randomized, double-blind, placebo-controlled trial. This pilot single-center, randomized, double-blind, placebo-co...

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Bibliographic Details
Published inBioMed research international Vol. 2018; p. 1613247
Main Authors Yoo, Ja-Young, Yum, Keun-Sang
Format Journal Article
LanguageEnglish
Published United States 2018
Subjects
Adult
Aged
Blood Glucose
Double-Blind Method
Female
Humans
Insulin
Insulin Resistance
Male
Middle Aged
Prediabetic State - drug therapy
Ubiquinone - analogs & derivatives
Ubiquinone - therapeutic use
Young Adult
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Summary:This study aimed to examine whether administration of coenzyme Q10, an antioxidant, improves insulin resistance in patients with prediabetes. The study design was a pilot single-center, randomized, double-blind, placebo-controlled trial. This pilot single-center, randomized, double-blind, placebo-controlled trial included a total of 80 adults (aged ≥20 years) with impaired glucose tolerance. After the initial screening visit, subjects were assigned to either the experimental (n = 40) or placebo (n = 40) group via simple randomization. Insulin resistance was represented as the insulin resistance index estimated by homeostasis model assessment (HOMA-IR). After the 8-week treatment period, the coenzyme group exhibited a significant decrease in the HOMA-IR (P < .001). The free oxygen radical and coenzyme Q10 concentrations were found to correlate significantly (P < .001). However, no significant changes in fasting blood glucose, insulin, and glycated hemoglobin levels were observed in either group. Additionally, no adverse events occurred in either group. Patients with prediabetes who were administered coenzyme Q10 showed a significant reduction in HOMA-IR values. Therefore, administration of coenzyme Q10 in patients with impaired glucose tolerance may slow the progression from prediabetes to overt diabetes.
ISSN:2314-6141