Anti-GABA B receptor encephalitis in a patient with gastric adenocarcinoma

Anti-γ-aminobutyric acid-B (GABA ) receptor encephalitis is an autoimmune encephalitis associated with antibodies against neuronal cell surface antigens, which are primarily observed with small-cell lung cancer, melanoma, and thymoma. Here, we first report a case on the association between a relativ...

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Bibliographic Details
Published inNeurological sciences
Main Authors Jia, Xiao-Tao, Pan, Yanfang, Di, Zhengli, Gu, Naibing, Liu, Zhiqin, Kang, Yu-Ming
Format Journal Article
LanguageEnglish
Published Italy 14.08.2018
Subjects
Chemotherapy
GABAB receptor
Immunotherapy
Gastric adenocarcinoma
Autoimmune encephalitis
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Summary:Anti-γ-aminobutyric acid-B (GABA ) receptor encephalitis is an autoimmune encephalitis associated with antibodies against neuronal cell surface antigens, which are primarily observed with small-cell lung cancer, melanoma, and thymoma. Here, we first report a case on the association between a relatively frequent cancer, gastric adenocarcinoma (GAC), and a rare GABA receptor antibody limbic encephalitis. The patient was treated with immunotherapy and combined-drug chemotherapy, which were partially effective in terms of stabilizing the tumor and relieving neurological symptoms. This report indicates that, when patients present with GABA receptor antibody limbic encephalitis, regular and broad screening for tumors including gastric adenocarcinoma should also be considered.
ISSN:1590-3478