1-α,25-dihydroxyvitamin D 3 potentiates avian osteoclast activation by increasing the formation of zipper-like structure via Src/Rac1 signaling

Avian bone metabolism diseases affect the development and production of chickens, and many of these diseases can be prevented and controlled by balanced nutrition and hormone medicine. The steroid hormone 1α,25-dihydroxyvitamin D plays a key role in maintaining the balance of avian bone metabolism....

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Bibliographic Details
Published inBiochemical and biophysical research communications
Main Authors Wang, Dong, Gu, Jian-Hong, Feng, Ling-Ling, Tong, Xi-Shuai, Song, Rui-Long, Zhao, Hong-Yan, Bian, Jian-Chun, Liu, Xue-Zhong, Yuan, Yan, Liu, Zong-Ping
Format Journal Article
LanguageEnglish
Published United States 14.05.2018
Subjects
1α,25-(OH)D
Src
Activation
Osteoclast
Rac1
Zipper-like structure
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Summary:Avian bone metabolism diseases affect the development and production of chickens, and many of these diseases can be prevented and controlled by balanced nutrition and hormone medicine. The steroid hormone 1α,25-dihydroxyvitamin D plays a key role in maintaining the balance of avian bone metabolism. Clinically, 1α,25-(OH) D has been used to treat several bone diseases. Although several previous studies have investigated the effects of 1α,25-(OH) D on osteoclastogenesis, the mechanisms underpinning osteoclast (OC) activity remain largely unknown. Herein, we used molecular and cell biology approaches to demonstrate that 1α,25-(OH) D increases avian OC formation and activity, and upregulates bone resorption-related genes. Moreover, 1α,25-(OH) D regulates the OC cytoskeleton by increasing the formation of zipper-like structure in OC precursor cells to potentiate OC activity via the Src/Rac1 signaling pathway. These findings provide new insight into the role of 1α,25-(OH) D in OC activity.
ISSN:1090-2104