Synthetic Inhibitors of Cell Adhesion: A Glycopeptide from E-Selectin Ligand 1 (ESL-1) with the Arabino Sialyl Lewis x Structure
Particularly selective methods are required for the synthesis of arabino sialyl Lewis glycopeptides owing to the acid-labile β-arabinopyranoside bond. It is important for the inhibition of cell adhesion that the arabino sialyl Lewis glycopeptide 1, which contains the Gly -Asp sequence of the E-sel...
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| Published in | Angewandte Chemie International Edition Vol. 40; no. 20; p. 3836 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Germany
15.10.2001
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Particularly selective methods are required for the synthesis of arabino sialyl Lewis
glycopeptides owing to the acid-labile β-arabinopyranoside bond. It is important for the inhibition of cell adhesion that the arabino sialyl Lewis
glycopeptide 1, which contains the Gly
-Asp
sequence of the E-selectin Ligand 1 (ESL-1), binds ten times more strongly than sialyl Lewis
to E-selectin, although it is monovalent and does not contain L-fucose, which is considered essential. |
|---|---|
| AbstractList | Particularly selective methods are required for the synthesis of arabino sialyl Lewis
glycopeptides owing to the acid-labile β-arabinopyranoside bond. It is important for the inhibition of cell adhesion that the arabino sialyl Lewis
glycopeptide 1, which contains the Gly
-Asp
sequence of the E-selectin Ligand 1 (ESL-1), binds ten times more strongly than sialyl Lewis
to E-selectin, although it is monovalent and does not contain L-fucose, which is considered essential. |
| Author | Kunz, Horst Vestweber, Dietmar Wild, Martin Rösch, Markus Dippold, Wolfgang Herzner, Holger |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/29712138$$D View this record in MEDLINE/PubMed |
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| Copyright | 2001 WILEY-VCH Verlag GmbH, Weinheim, Fed. Rep. of Germany. |
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| Issue | 20 |
| Keywords | glycopeptides E-selectin ligand allyl anchor sialyl Lewisx mimetica solid-phase synthesis |
| Language | English |
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| Snippet | Particularly selective methods are required for the synthesis of arabino sialyl Lewis
glycopeptides owing to the acid-labile β-arabinopyranoside bond. It is... |
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| Title | Synthetic Inhibitors of Cell Adhesion: A Glycopeptide from E-Selectin Ligand 1 (ESL-1) with the Arabino Sialyl Lewis x Structure |
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