Synthetic Inhibitors of Cell Adhesion: A Glycopeptide from E-Selectin Ligand 1 (ESL-1) with the Arabino Sialyl Lewis x Structure
Particularly selective methods are required for the synthesis of arabino sialyl Lewis glycopeptides owing to the acid-labile β-arabinopyranoside bond. It is important for the inhibition of cell adhesion that the arabino sialyl Lewis glycopeptide 1, which contains the Gly -Asp sequence of the E-sel...
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Published in | Angewandte Chemie International Edition Vol. 40; no. 20; p. 3836 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Germany
15.10.2001
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Subjects | |
Online Access | Get full text |
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Summary: | Particularly selective methods are required for the synthesis of arabino sialyl Lewis
glycopeptides owing to the acid-labile β-arabinopyranoside bond. It is important for the inhibition of cell adhesion that the arabino sialyl Lewis
glycopeptide 1, which contains the Gly
-Asp
sequence of the E-selectin Ligand 1 (ESL-1), binds ten times more strongly than sialyl Lewis
to E-selectin, although it is monovalent and does not contain L-fucose, which is considered essential. |
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ISSN: | 1521-3773 |