Remodeling of the HDL in NIDDM: a fundamental role for cholesteryl ester transfer protein

• Published in: American journal of physiology: endocrinology and metabolism Vol. 274; no. 6; p. E1091
• Main Authors: Castle, Christine K, Kuiper, Susan L, Blake, William L, Paigen, Beverly, Marotti, Keith R, Melchior, George W
• Format: Journal Article
• Language: English
• Published: United States 01.06.1998
• Subjects: high-density lipoprotein lipase; KKAy mouse; free apolipoprotein A-I; pre-β apolipoprotein A-I; mouse model of non-insulin-dependent diabetes mellitus; mouse plasma lipase

When the A gene is expressed in KK mice, the yellow offspring (KKA mice) become obese, insulin resistant, hyperglycemic, and severely hypertriglyceridemic, yet they maintain extraordinarily high plasma high-density lipoprotein (HDL) levels. Mice lack the ability to redistribute neutral lipids among...