Supramolecular cyclodextrin-based metal-organic framework as efficient carriers for anti-inflammatory drugs

Drug delivery systems have been used to reduce adverse effects and improve the efficacy of therapies. Drug carriers have been developed over the years, but they have limitations. γ-cyclodextrin-based metal-organic frameworks (γ-CD-MOF) have significant advantages due to their biocompatibility and en...

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Published inEuropean journal of pharmaceutics and biopharmaceutics
Main Authors Abuçafy, Marina P, Caetano, Bruno L, Chiari-Andréo, Bruna G, Fonseca-Santos, Bruno, do Santos, Aline M, Chorilli, Marlus, Chiavacci, Leila A
Format Journal Article
LanguageEnglish
Published Netherlands 08.02.2018
Subjects
anti-inflammatory in vivo assay
γ-cyclodextrin, drug adsorption
drug delivery
metal-organic framework
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Summary:Drug delivery systems have been used to reduce adverse effects and improve the efficacy of therapies. Drug carriers have been developed over the years, but they have limitations. γ-cyclodextrin-based metal-organic frameworks (γ-CD-MOF) have significant advantages due to their biocompatibility and environmental safety, besides crystallinity and porosity. Herein, γ-CD-MOFs were synthesised with different metals as nodes and investigated. Uniform mesoporous γ-CD-MOFs were obtained and showed an absence of toxicity in HepG2 and Caco-2 cells. The longer controlled release was verified for γ-CD-MOFs, with a maximum of 62% released in 12h. An inflammation experiment was performed in mice and activity equivalent to the positive control was verified. γ-KCD-MOFs and γ-NaCD-MOFs reached activity after 6h of administration, however this happened after 24 h in γ-FeCD-MOFs, being more effective than the positive control. Considering the ability for drug entrapment, easy preparation and controlled release, this class of material allows potential applications in drug delivery systems.
ISSN:1873-3441