Association of REL Polymorphism with Cow's Milk Proteins Allergy in Pediatric Algerian Population. Association REL Polymorphism with Cow's Milk Proteins Allergy

Cow's milk proteins allergy (CMPA) pathogenesis involves complex immunological mechanisms with the participation of several cells and molecules involved in food allergy. The association of polymorphisms in the interleukin 4, Forkhead box P3 and the avian reticuloendotheliosis genes was investig...

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Bibliographic Details
Published inFetal and pediatric pathology p. 1
Main Authors Rahmoun, Nesrine, El Mecherfi, Kamel Eddine, Bouchetara, Assia, Lardjem Hetraf, Sara, Dahmani Amira, Chahinez, Adda Neggaz, Leila, Boudjema, Abdallah, Zemani-Fodil, Faouzia, Saidi, Djamel, Kheroua, Omar
Format Journal Article
LanguageEnglish
Published England 16.01.2018
Subjects
IL4
Cow's milk proteins allergy
REL
FoxP3
polymorphisms
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Summary:Cow's milk proteins allergy (CMPA) pathogenesis involves complex immunological mechanisms with the participation of several cells and molecules involved in food allergy. The association of polymorphisms in the interleukin 4, Forkhead box P3 and the avian reticuloendotheliosis genes was investigated in an infant population with CMPA of Western Algeria. We obtained DNA and clinical data from milk allergic subjects during active phase and from a group of non-atopic control subjects. Our findings showed that the allele G of the cRel gene intronic polymorphism at +7883 positions was significantly higher among cow's milk proteins allergic patients compared to control subjects. The results of this study suggest a possible association of CMPA with cRel G+7883T polymorphism.
ISSN:1551-3823