Successful treatment of acute promyelocytic leukaemia without chemotherapy and blood transfusion

Untreated acute promyelocytic leukaemia (APL) is a rapidly lethal blood cancer. Conventional treatment consists of all-trans retinoic acid and chemotherapy. Standard chemo-therapy-containing treatments necessitate the use of blood products. This is a case report of typical APL in a 32-year-old femal...

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Bibliographic Details
Published inUgeskrift for læger Vol. 180; no. 3
Main Authors Tøstesen, Michael, Østgård, Lene S G, Kjeldsen, Eigil, Stentoft, Jesper, Nørgaard, Jan M
Format Journal Article
LanguageDanish
Published Denmark 15.01.2018
Subjects
Adult
Antineoplastic Agents - administration & dosage
Antineoplastic Agents - therapeutic use
Arsenic Trioxide - administration & dosage
Arsenic Trioxide - therapeutic use
Female
Humans
Leukemia, Promyelocytic, Acute - drug therapy
Religion and Medicine
Treatment Outcome
Treatment Refusal
Tretinoin - administration & dosage
Tretinoin - therapeutic use
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Summary:Untreated acute promyelocytic leukaemia (APL) is a rapidly lethal blood cancer. Conventional treatment consists of all-trans retinoic acid and chemotherapy. Standard chemo-therapy-containing treatments necessitate the use of blood products. This is a case report of typical APL in a 32-year-old female patient, who due to religious conviction refused supportive therapy with blood products. A treatment regimen consisting of all-trans retinoic acid and arsenic trioxide was successful without the use of blood transfusions.
ISSN:1603-6824