A chiral template-driven synthesis of a 3'-deoxy-3'- 18 F-fluorothymidine precursor

An asymmetric synthesis of a 3'-deoxy-3'- F-fluorothymidine ( F-FLT) precursor has been developed wherein the deoxysugar moiety was synthesized using a novel Ga-mediated allylation of (R)-2,3-cyclohexylideneglyceraldehyde as the key step. The synthesis deviates significantly from the previ...

Full description

Saved in:
Bibliographic Details
Published inEuropean journal of medicinal chemistry Vol. 143; p. 1457
Main Authors Dey, Papiya, Ajish Kumar, K S, Sharma, Anubha, Chattopadhyay, Subrata
Format Journal Article
LanguageEnglish
Published France 01.01.2018
Subjects
Asymmetric synthesis
PET imaging agent
Chiral template
FLT
Online AccessGet full text

Cover

More Information
Summary:An asymmetric synthesis of a 3'-deoxy-3'- F-fluorothymidine ( F-FLT) precursor has been developed wherein the deoxysugar moiety was synthesized using a novel Ga-mediated allylation of (R)-2,3-cyclohexylideneglyceraldehyde as the key step. The synthesis deviates significantly from the previous syntheses of the F-FLT precursors wherein the expensive starting material, thymidine was used.
ISSN:1768-3254