Differentiating malignant from benign thyroid nodules with indeterminate cytology by 99m Tc-MIBI scan: a new quantitative method for improving diagnostic accuracy

Quantitative Tc-MIBI thyroid scintigraphy is a useful tool in differentiating malignant from benign thyroid nodules with indeterminate cytology. The aim of our report is to compare the diagnostic performance of different quantitative methods. We prospectively evaluated 20 patients affected by a thyr...

Full description

Saved in:
Bibliographic Details
Published inScientific reports Vol. 7; no. 1; p. 6147
Main Authors Campennì, A, Siracusa, M, Ruggeri, R M, Laudicella, R, Pignata, S A, Baldari, S, Giovanella, L
Format Journal Article
LanguageEnglish
Published England 21.07.2017
Subjects
Adult
Aged
Aged, 80 and over
Cytodiagnosis - methods
Diagnosis, Differential
Female
Humans
Middle Aged
Prospective Studies
Radionuclide Imaging - methods
Radiopharmaceuticals - administration & dosage
Sensitivity and Specificity
Technetium Tc 99m Sestamibi - administration & dosage
Thyroid Neoplasms - diagnostic imaging
Thyroid Neoplasms - pathology
Thyroid Neoplasms - surgery
Thyroid Nodule - diagnostic imaging
Thyroid Nodule - pathology
Thyroid Nodule - surgery
Thyroidectomy
Young Adult
Online AccessGet full text

Cover

More Information
Summary:Quantitative Tc-MIBI thyroid scintigraphy is a useful tool in differentiating malignant from benign thyroid nodules with indeterminate cytology. The aim of our report is to compare the diagnostic performance of different quantitative methods. We prospectively evaluated 20 patients affected by a thyroid nodule with a cytological diagnosis of class III or IV according to the Bethesda system. Planar images of the thyroid were acquired 10 and 60 minutes after Tc-MIBI administration and two different quantitative methods applied (i.e. wash-out index, WOind; retention index, R.I.). All patients underwent lobectomy or thyroidectomy and final histological findings were matched with MIBI results obtained with both quantitative methods. Four out of 20 patients had a final histological result of differentiated thyroid cancer, while benign findings were found in the remaining cases. Overall sensitivity, specificity, accuracy, PPV and NPV were 100% in all for the WOind and 100%, 57.1%, 62.5%, 25% for the R.I., respectively. In conclusion Tc-semiquantitative MIBI thyroid scintigraphy with WOind calculation is highly accurate in differential diagnosis of nodules with indeterminate cytology reading.
ISSN:2045-2322