Limitation of phage multiplication by microbes of the genus Bordetella

Possible causes limiting the multiplication of Bordetella phages or inducing their restriction, such as the influence of lysogenic immunity and the restriction-modification (R-M) system or the incompatibility of the receptor apparatus, have been studied. The limitation of the multiplication of phage...

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Bibliographic Details
Published inŽurnal mikrobiologii, ėpidemiologii i immunobiologii no. 12; p. 35
Main Authors Lapaeva, I A, Rebentish, B A, Mebel', S M, Kalinin, V N, Vavilova, E Iu
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.12.1985
Subjects
Adsorption
Bacteriophages - drug effects
Bacteriophages - physiology
Bordetella - enzymology
Bordetella - immunology
Bordetella pertussis - enzymology
Bordetella pertussis - immunology
DNA Restriction Enzymes - pharmacology
Lysogeny
Phenotype
Virus Replication - drug effects
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Summary:Possible causes limiting the multiplication of Bordetella phages or inducing their restriction, such as the influence of lysogenic immunity and the restriction-modification (R-M) system or the incompatibility of the receptor apparatus, have been studied. The limitation of the multiplication of phages by some B. bronchiseptica and B. pertussis strains has been shown to be due to the presence of the R-M system and lysogenic immunity. In five B. bronchiseptica strains and two B. pertussis strains site-specific endonucleases (restrictases) with Hind III specificity have been detected. One B. bronchiseptica strain without the R-M system has been detected. B. bronchiseptica strains producing site-specific endonucleases are practically nonpathogenic for humans, grow in common culture media and selectively produce only one restrictase, type Hind III, which guarantees from the admixture of other specific endonucleases. The B. parapertussis strains under study (altogether 100 strains) have not been found to limit the multiplication of Bordetella test phages. The absence of site-specific endonucleases has also been confirmed biochemically. These strains are recommended as indicator strains for the multiplication of Bordetella phages.
ISSN:0372-9311