Scintigraphic imaging of Staphylococcus aureus infection using 99m Tc radiolabeled aptamers

Staphylococcus aureus is a specie of great medical importance associated with many infections as bacteremia and infective endocarditis as well as osteoarticular, skin and soft tissue, pleuropulmonary, and device related infections. Early identification of infectious foci is crucial for successful tr...

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Bibliographic Details
Published inApplied radiation and isotopes Vol. 128; p. 22
Main Authors Santos, Sara Roberta Dos, de Sousa Lacerda, Camila Maria, Ferreira, Iêda Mendes, de Barros, André Luís Branco, Fernandes, Simone Odília, Cardoso, Valbert Nascimento, de Andrade, Antero Silva Ribeiro
Format Journal Article
LanguageEnglish
Published England 01.10.2017
Subjects
Animals
Aptamers, Nucleotide - administration & dosage
Aptamers, Nucleotide - metabolism
Aptamers, Nucleotide - pharmacokinetics
Blood Proteins - metabolism
Mice
Organotechnetium Compounds - administration & dosage
Organotechnetium Compounds - pharmacokinetics
Radionuclide Imaging - methods
Radiopharmaceuticals - administration & dosage
Radiopharmaceuticals - pharmacokinetics
Staphylococcal Infections - diagnostic imaging
Staphylococcal Infections - microbiology
Staphylococcus aureus - isolation & purification
Tissue Distribution
Bacterial infection
Radiopharmaceutical
Aptamer
Diagnosis
Technetium-99m
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Summary:Staphylococcus aureus is a specie of great medical importance associated with many infections as bacteremia and infective endocarditis as well as osteoarticular, skin and soft tissue, pleuropulmonary, and device related infections. Early identification of infectious foci is crucial for successful treatment. Scintigraphy could contribute to this purpose since specific radiotracers were available. Aptamers due to their high specificity have great potential for radiopharmaceuticals development. In the present study scintigraphic images of S. aureus infectious foci were obtained using specific S. aureus aptamers radiolabeled with Tc.
ISSN:1872-9800