Toxic megacolon as a rare complication following atropine therapy due to organophosphate poisoning: A case report

The main therapeutic basis for a case of organophosphate poisoning is a combination therapy which includes atropine as an anticholinergic drug and pralidoxime. If the poisoning is severe, a high dose of this combination of medicines may be needed, but this may cause serious side effects: paralytic i...

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Bibliographic Details
Published inThe Medico-legal journal Vol. 85; no. 4; p. 221
Main Authors Mostafazadeh, Babak, Farzaneh, Esmaeil, Paeezi, Maryam, Nikkhah, Farahnaz
Format Journal Article
LanguageEnglish
Published England 01.12.2017
Subjects
toxic megacolon
Organophosphate
poisoning
atropine
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Summary:The main therapeutic basis for a case of organophosphate poisoning is a combination therapy which includes atropine as an anticholinergic drug and pralidoxime. If the poisoning is severe, a high dose of this combination of medicines may be needed, but this may cause serious side effects: paralytic ileus or even megacolon; however, these gastrointestinal events are very rare. Here, we report a case of organophosphate poisoning where atropine therapy was given and led to drug-associated toxic megacolon.
ISSN:2042-1834