Levels of salivary thiocyanate and its relation with occurrence of micronuclei using exfoliative cytology in smokers and nonsmokers

To evaluate the levels of salivary thiocyanate and its relation with the occurrence of micronuclei (MN) using exfoliative cytology in smokers and nonsmokers. One hundred and twenty patients were divided into 3 groups: nonsmoker group 1 (control), smokers group 2, and smokers group 3. Their saliva wa...

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Published inIndian journal of dental research : official publication of Indian Society for Dental Research Vol. 27; no. 6; p. 568
Main Authors Baldawa, Prachi Shrigopal, Kulkarni, Venkatesh V, Koshy, Ajit V, Shaikh, Sabeer S, Varu, Rucha, Srivastava, Garima
Format Journal Article
LanguageEnglish
Published India 01.11.2016
Subjects
Adult
Biomarkers - analysis
Cytodiagnosis - methods
Diagnosis, Oral - methods
Humans
Lobeline
Micronucleus Tests - methods
Middle Aged
Mouth Mucosa - pathology
Mouth Neoplasms - prevention & control
Saliva - chemistry
Smokers
Smoking - pathology
Thiocyanates - analysis
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Summary:To evaluate the levels of salivary thiocyanate and its relation with the occurrence of micronuclei (MN) using exfoliative cytology in smokers and nonsmokers. One hundred and twenty patients were divided into 3 groups: nonsmoker group 1 (control), smokers group 2, and smokers group 3. Their saliva was collected and analyzed for thiocyanate levels, and exfoliative cytology was evaluated for the presence of MN. Fisher's exact test and ANOVA test were used. It was seen that as the grade of smoking increased, the levels of salivary thiocyanate and occurrence of MN increased. Detection and quantification of "biomarkers" such as salivary thiocyanate and MN in noninvasive and painless procedures such as oral exfoliative cytology can be an upcoming research domain in the field of cancer prevention and therapeutics.
ISSN:1998-3603