A review of 3D image-based dosimetry, technical considerations and emerging perspectives in 90 Y microsphere therapy

Yttrium-90 radioembolization ( Y-RE) is a well-established therapy for the treatment of hepatocellular carcinoma (HCC) and also of metastatic liver deposits from other malignancies. Nuclear Medicine and Cath Lab diagnostic imaging takes a pivotal role in the success of the treatment, and in order to...

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Bibliographic Details
Published inJournal of diagnostic imaging in therapy Vol. 2; no. 2; p. 1
Main Author O' Doherty, Jim
Format Journal Article
LanguageEnglish
Published Northern Ireland 2015
Subjects
90Y microspheres
Monte Carlo
dosimetry
molecular radiotherapy
hepatocellular carcinoma
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Summary:Yttrium-90 radioembolization ( Y-RE) is a well-established therapy for the treatment of hepatocellular carcinoma (HCC) and also of metastatic liver deposits from other malignancies. Nuclear Medicine and Cath Lab diagnostic imaging takes a pivotal role in the success of the treatment, and in order to fully exploit the efficacy of the technique and provide reliable quantitative dosimetry that are related to clinical endpoints in the era of personalized medicine, technical challenges in imaging need to be overcome. In this paper, the extensive literature of current Y-RE techniques and challenges facing it in terms of quantification and dosimetry are reviewed, with a focus on the current generation of 3D dosimetry techniques. Finally, new emerging techniques are reviewed which seek to overcome these challenges, such as high-resolution imaging, novel surgical procedures and the use of other radiopharmaceuticals for therapy and pre-therapeutic planning.
ISSN:2057-3782
2057-3782