The role of the bone marrow in forming an immunological memory to Staphylococcus

The dynamic study of antibody formation in the bone marrow tissue of mice immunized with corpuscular staphylococcal antigen was made. A single intravenous injection of this antigen to the animals produced no essential changes in the number of antibody-forming cells in the bone marrow, their repeated...

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Bibliographic Details
Published inŽurnal mikrobiologii, ėpidemiologii i immunobiologii no. 1; p. 69
Main Authors Bobrovnik, S A, Liashchenko, K P
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.01.1989
Subjects
Animals
Antibodies, Bacterial - analysis
Antibody-Producing Cells - immunology
Antigens, Bacterial - immunology
Bone Marrow - immunology
Immunization
Immunization, Secondary
Immunologic Memory
Mice
Mice, Inbred CBA
Spleen - immunology
Staphylococcus aureus - immunology
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Summary:The dynamic study of antibody formation in the bone marrow tissue of mice immunized with corpuscular staphylococcal antigen was made. A single intravenous injection of this antigen to the animals produced no essential changes in the number of antibody-forming cells in the bone marrow, their repeated immunization led to the involvement of the bone marrow in the anamnetic reaction, which was manifested by the accumulation of a great number of plasmocytes synthesizing antibodies to staphylococci in bone marrow tissue. The relative contribution of the bone marrow to systemic antibody formation essentially increased at later stages of secondary immune response. The possible biological significance of the regularities and the practical importance of the data revealed in this investigation are discussed.
ISSN:0372-9311