THE BIOMARKERS FOR TIMELY DIAGNOSTICS OF COLORECTAL CANCER

The colorectal cancer (CC) is one of the most widespread type of cancer all over the world. It is confirmed that the screening procedures intended for timely detection of CC and adenomatous polyps, significantly decrease mortality. The colonoscopy and analysis offeces for occult blood are widely app...

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Published inKlinicheskaia laboratornaia diagnostika Vol. 60; no. 12; p. 15
Main Authors Sokolova, E A, Boyarskikh, U A, Shirshova, A N, Kel, A E, Filipenko, M L
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.12.2015
Subjects
Adenomatous Polyps - diagnosis
Adenomatous Polyps - genetics
Adenomatous Polyps - metabolism
Adenomatous Polyps - pathology
Biomarkers, Tumor - genetics
Biomarkers, Tumor - metabolism
Colonoscopy
Colorectal Neoplasms - diagnosis
Colorectal Neoplasms - genetics
Colorectal Neoplasms - metabolism
Colorectal Neoplasms - pathology
Early Diagnosis
Feces - chemistry
Gene Expression Regulation, Neoplastic
Humans
Mass Screening
MicroRNAs - genetics
MicroRNAs - metabolism
Neoplasm Proteins - genetics
Neoplasm Proteins - metabolism
Occult Blood
Reagent Kits, Diagnostic
Transcription Factors - genetics
Transcription Factors - metabolism
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Summary:The colorectal cancer (CC) is one of the most widespread type of cancer all over the world. It is confirmed that the screening procedures intended for timely detection of CC and adenomatous polyps, significantly decrease mortality. The colonoscopy and analysis offeces for occult blood are widely applied as screening procedures. However, they have a number of shortcomings. The studies of the last decade revealed number of genetic and epigenetic markers potentially permitting revealing patients with CC at early stages of development of disease. The article analyzes CC-specific microRNA and their possible interactions with different transcriptional factors. These factors, being integrated into the structure of so called network s with direct signal propagation, ensure special stability of all regulatory system. The derangement of functioning of these networks quite often results in pathological alterations.
ISSN:0869-2084