EFFECT OF NEONATAL SEIZURES ON THE SYNAPTIC PLASTICITY OF RAT SOMATOSENSORY CORTEX

• Published in: Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994) Vol. 61; no. 6; p. 11
• Main Authors: Isaeva, E V, Lunko, O O, Romano, A K, Isaev, D S
• Format: Journal Article
• Language: Ukrainian
• Published: Ukraine 2015
• Subjects: Animals; Animals, Newborn; Convulsants - pharmacology; Epilepsy - chemically induced; Epilepsy - pathology; Epilepsy - physiopathology; Excitatory Postsynaptic Potentials - drug effects; Flurothyl - pharmacology; Humans; Inhibitory Postsynaptic Potentials - drug effects; Long-Term Potentiation - drug effects; Male; Neurons - drug effects; Neurons - pathology; Rats, Sprague-Dawley; Somatosensory Cortex - drug effects; Somatosensory Cortex - pathology; Somatosensory Cortex - physiopathology; Synaptic Transmission - drug effects

Using an experimental model of neonatal recurrent seizures we investigated the influence of epileptic seizures in the various forms of synaptic plasticity in neurons of the somatosensory cortex. We found that early seizures do not affect the post-tetanic potentiation of the amplitude of the postsyna...