EFFECT OF NEONATAL SEIZURES ON THE SYNAPTIC PLASTICITY OF RAT SOMATOSENSORY CORTEX

Using an experimental model of neonatal recurrent seizures we investigated the influence of epileptic seizures in the various forms of synaptic plasticity in neurons of the somatosensory cortex. We found that early seizures do not affect the post-tetanic potentiation of the amplitude of the postsyna...

Full description

Saved in:
Bibliographic Details
Published inFiziolohichnyi zhurnal (Kiev, Ukraine : 1994) Vol. 61; no. 6; p. 11
Main Authors Isaeva, E V, Lunko, O O, Romano, A K, Isaev, D S
Format Journal Article
LanguageUkrainian
Published Ukraine 2015
Subjects
Animals
Animals, Newborn
Convulsants - pharmacology
Epilepsy - chemically induced
Epilepsy - pathology
Epilepsy - physiopathology
Excitatory Postsynaptic Potentials - drug effects
Flurothyl - pharmacology
Humans
Inhibitory Postsynaptic Potentials - drug effects
Long-Term Potentiation - drug effects
Male
Neurons - drug effects
Neurons - pathology
Rats, Sprague-Dawley
Somatosensory Cortex - drug effects
Somatosensory Cortex - pathology
Somatosensory Cortex - physiopathology
Synaptic Transmission - drug effects
Online AccessGet full text

Cover

More Information
Summary:Using an experimental model of neonatal recurrent seizures we investigated the influence of epileptic seizures in the various forms of synaptic plasticity in neurons of the somatosensory cortex. We found that early seizures do not affect the post-tetanic potentiation of the amplitude of the postsynaptic potentials and the depression of postsynaptic potentials during high-frequency stimulation. However they result in the chronic increase of the long-term potentiation of synaptic transmission. These changes of synaptic plasticity may affect the processing of the sensory information in patients with a history of recurrent seizures during early development.
ISSN:2522-9028