THE TEST OF GENERATION OF THROMBIN IN DYNAMICS IN PATIENTS AFTER TRANSCUTANEOUS CORONARY INTERVENTION

• Published in: Klinicheskaia laboratornaia diagnostika Vol. 60; no. 4; p. 40
• Main Authors: Napalkova, O S, Emanuel, V L, Karpenko, M A, Berezovskaia, G A, Iakovlev, A N, Yudina, V A, Vasilieva, E Yu, Lapin, S V, Tishkov, A V, Hisheva, N A
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 01.04.2015
• Subjects: Adult; Aged; Annexin A5 - blood; Biomarkers - blood; Female; Fibrinogen - metabolism; Humans; Male; Middle Aged; Myocardial Ischemia - blood; Myocardial Ischemia - therapy; Percutaneous Coronary Intervention; Protein C - metabolism; Thrombin Time - methods
• ISSN: 0869-2084

The article presents results of observation of generation of thrombin in patients with ischemic heart disease in different terms after transcutaneous coronary intervention. The sampling included 37 patients with stable ischemic heart disease. The control group included 30 healthy individuals. To study system of hemostasis of this category of patients the test of generation of thrombin and its modification with added thrombomodulin were applied for evaluating anti-coagulant activity of system of protein C. The comparison of indicators of test of generation of thrombin in patients with ischemic heart disease before operation and in individuals of control group revealed no reliable differences (p > 0.05). The observation of patients with stable ischemic heart disease in various time-frame after mechanical re-vascularization of myocardium established significant increasing of generation of thrombin and decreasing of anticoagulant activity of system of protein C at 1-3 day after operation (p < 0.05). The positive correlation was established between endogenous thrombin potential and annexin 5, an early marker of dysfunction of endothelium in mentioned time-frame after operation (p = 0.0008; r = 0.57). The significant increasing of content of anti-inflammatory markers of C-reactive protein and fibrinogen was observed at 1-3 day after transcutaneous coronary intervention (p < 0.05). In that way, the study data give evidence to hyper-coagulation in patients with stable ischemic heart disease in early time-frame after operation despite normal values of activated partial thromboplastin time, prothrombin time, D-dimer and applied standard disaggregant therapy.