Modern approaches to the synchronization of circadian rhythms in treatment of depression

In this review, we have analyzed the association between chronobiological disorders and depressive symptoms, and outlined new antidepressant therapeutic strategies aimed at restoring normal functioning of the circadian system. It is specifically noted that the drug valdoxan, an agonist of melatonin...

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Bibliographic Details
Published inZhurnal nevrologii i psikhiatrii imeni S.S. Korsakova Vol. 114; no. 11; p. 124
Main Authors Barylnik, J B, Filippova, N V, Trayber, L V
Format Journal Article
LanguageRussian
Published Russia (Federation) 2014
Subjects
Acetamides - pharmacology
Acetamides - therapeutic use
Animals
Circadian Rhythm - drug effects
Depression - drug therapy
Depression - metabolism
Depression - physiopathology
Humans
Hypnotics and Sedatives - pharmacology
Hypnotics and Sedatives - therapeutic use
Receptors, Melatonin - agonists
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Summary:In this review, we have analyzed the association between chronobiological disorders and depressive symptoms, and outlined new antidepressant therapeutic strategies aimed at restoring normal functioning of the circadian system. It is specifically noted that the drug valdoxan, an agonist of melatonin receptors and selective antagonist of serotoninergic 5-HT2C receptors has chronobiotic,antidepressive and anxiolytic action. In its antidepressive effect, valdoxan is comparable to venlafaxine, fluoxetine and sertraline.Recurrences of depression is noted in fewer patients (23,9 %) treated with valdoxan compared to placebo (50,0 %). The drug improves sleep quality as well. As the drug does not cause the increase in serotonin levels, it has considerably less side-effects of the gastrointestinal tract, sexual sphere, or metabolic processes, characteristic of many other antidepressants.
ISSN:1997-7298