The relationship of Bradykinin B₂ receptor gene variation with obesity, hypertension and lipid variables in obese patients

• Published in: Acta medica academica Vol. 43; no. 2; p. 144
• Main Authors: Bakir, Nur, Bozkuş, Hasan Mert, Koldemir Gündüz, Meliha, Çağatay, Penbe, Taşkın, Mustafa, Süsleyici Duman, Belgin
• Format: Journal Article
• Language: English
• Published: Bosnia and Herzegovina 2014
• Subjects: Adult; Aged; Aged, 80 and over; Alleles; Blood Pressure; Body Mass Index; Cholesterol - blood; Cholesterol - genetics; Diuretics - therapeutic use; Female; Gene Frequency; Genotype; Humans; Hypertension - drug therapy; Hypertension - genetics; Hypoglycemic Agents - therapeutic use; Logistic Models; Male; Middle Aged; Obesity - genetics; Polymorphism, Genetic; Receptor, Bradykinin B2 - genetics; Waist Circumference
• ISSN: 1840-2879

This study examined the association of C-58T genotypes with obesity/hypertension related parameters and serum lipids in obese (n=108) and non-obese (n=80) patients. Bradykinin receptor (B₂R) C-58T genotypes were determined by PCR-RFLP. B₂R gene C-58T frequencies for T/T (homozygous wild type), T/C (heterozygous) and C/C (homozygous polymorphic) genotypes for obese and non-obese patients were respectively: 36.1%, 37.5%; 45.4%, 52.5% and 18.5%, 10%. Obese patients using diuretic medication had lower C/C genotype frequency compared to T/T and T/C genotypes. Total cholesterol (T-Chol) (p=0.035) levels were found to be associated with B₂R C-58T polymorphism, where the T/T genotype had higher total cholesterol levels compared to the T/C genotype in obese patients. Non-obese patients using oral antidiabetic medication had higher C/C genotype frequency than that of T/T and T/C genotypes. Waist circumference (p=0.016) and diastolic blood pressure (p=0.01) levels were elevated in the non-obese subjects with the C/C genotype compared to T/C and T/T. Although B₂R C-58T gene polymorphism was not found to be effective on obesity with logistic regression analysis in the whole study population in obese subjects, the T-Chol decreasing effect of the B₂R gene C allele and the higher waist circumference measurements in the non-obese subjects may indicate there may be a link between B₂R gene C-58T polymorphism and obesity in study populations of higher numbers.