Poly(oligonucleotide)

Here we report the preparation of poly(oligonucleotide) brush polymers and amphiphilic brush copolymers from nucleic acid monomers via graft-through polymerization. We describe the polymerization of PNA-norbornyl monomers to yield poly-PNA (poly(peptide nucleic acid)) via ring-opening metathesis pol...

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Bibliographic Details
Published inJournal of the American Chemical Society Vol. 136; no. 32; p. 11216
Main Authors James, Carrie R, Rush, Anthony M, Insley, Thomas, Vuković, Lela, Adamiak, Lisa, Král, Petr, Gianneschi, Nathan C
Format Journal Article
LanguageEnglish
Published United States 13.08.2014
Subjects
DNA - chemistry
DNA, Single-Stranded - chemistry
Magnetic Resonance Spectroscopy
Nanoparticles - chemistry
Oligonucleotides - chemistry
Peptide Nucleic Acids - chemistry
Polymerization
Polymers - chemistry
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Summary:Here we report the preparation of poly(oligonucleotide) brush polymers and amphiphilic brush copolymers from nucleic acid monomers via graft-through polymerization. We describe the polymerization of PNA-norbornyl monomers to yield poly-PNA (poly(peptide nucleic acid)) via ring-opening metathesis polymerization (ROMP) with the initiator, (IMesH2)(C5H5N)2(Cl)2RuCHPh.1 In addition, we present the preparation of poly-PNA nanoparticles from amphiphilic block copolymers and describe their hybridization to a complementary single-stranded DNA (ssDNA) oligonucleotide.
ISSN:1520-5126