Case of exogenous insulin-derived acanthosis nigricans caused by insulin injections

A 73-year-old male with diabetes mellitus had been treated with insulin for six years. He developed a solid mass on his left lateral of the abdomen at the insulin injection site. A firm subcutaneous mass with dark-red erythema was overlaid by dark-brown keratinized plaques. On histological examinati...

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Bibliographic Details
Published inThe Tokai journal of experimental and clinical medicine Vol. 39; no. 1; p. 5
Main Authors Yahagi, Eiichiro, Mabuchi, Tomotaka, Nuruki, Hiroko, Manabe, Yasuaki, Ikoma, Norihiro, Ozawa, Akira, Yamamoto, Naoyuki, Tanaka, Eitaro, Sekido, Yasutomo, Matsuyama, Takashi
Format Journal Article
LanguageEnglish
Published Japan 20.03.2014
Subjects
Acanthosis Nigricans - chemically induced
Acanthosis Nigricans - metabolism
Acanthosis Nigricans - pathology
Aged
Humans
Injections, Subcutaneous
Insulin - administration & dosage
Insulin - adverse effects
Male
Receptor, IGF Type 1 - metabolism
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Summary:A 73-year-old male with diabetes mellitus had been treated with insulin for six years. He developed a solid mass on his left lateral of the abdomen at the insulin injection site. A firm subcutaneous mass with dark-red erythema was overlaid by dark-brown keratinized plaques. On histological examination of the mass, keratin proliferation and epidermal papilloma were observed. There were four previously reported cases of acanthosis nigricans that were considered to be caused by continuous injections of insulin. Using immunohistochemistry, in our case the findings were positive in the basal epithelial and prickle cell layers when the patient's lesion was dyed with insulin-like growth factor (IGF)-1 antibody. The coexistence of dermal IGF-1 receptor and acanthosis nigricans found in our patient has not been reported previously, to our knowledge.
ISSN:2185-2243