Adjuvant properties of polymer based on acrylic acid

Adjuvant properties of the polymer containing acrylic acid, glycidyl methacrylate, triethylene glycol methacrylate and butyl acrylate have been established. Antibodies to ovalbumin and bovine serum albumin in the blood of mice were revealed using dot blot analysis and immunoenzyme analysis when appl...

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Bibliographic Details
Published inUkrains'kyi biokhimichnyi zhurnal (1999 ) Vol. 85; no. 3; p. 69
Main Authors Kozak, M R, Oliĭnyk, A V, Zaichenko, O S, Vlizlo, V V
Format Journal Article
LanguageUkrainian
Published Ukraine 01.05.2013
Subjects
Acrylic Resins - chemistry
Adjuvants, Immunologic - administration & dosage
Adjuvants, Immunologic - chemical synthesis
Aluminum Hydroxide - administration & dosage
Aluminum Hydroxide - immunology
Animals
Antibodies - blood
Antigens - administration & dosage
Antigens - immunology
Cattle
Mice
Ovalbumin - administration & dosage
Ovalbumin - immunology
Polymerization
Serum Albumin, Bovine - administration & dosage
Serum Albumin, Bovine - immunology
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Summary:Adjuvant properties of the polymer containing acrylic acid, glycidyl methacrylate, triethylene glycol methacrylate and butyl acrylate have been established. Antibodies to ovalbumin and bovine serum albumin in the blood of mice were revealed using dot blot analysis and immunoenzyme analysis when applying the investigated polymer as a carrier of these protein antigens. Adjuvant properties of the polymer were compared to aluminum hydroxide, which is a component of many traditional vaccines. Experimental polymer was a stronger adjuvant because it led to an increase of specific antibodies against ovalbumin and bovine serum albumin.