Intestine infections, inflammation and autoimmunity. Lymphoid apparatus of intestine in interaction with intestine microflora

• Published in: Žurnal mikrobiologii, ėpidemiologii i immunobiologii no. 1; p. 113
• Main Authors: Balmasova, I P, Sepiashvili, R I
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 01.01.2013
• Subjects: Animals; Antigens, Bacterial - immunology; Autoimmunity; Bacterial Infections - immunology; Bacterial Infections - microbiology; Humans; Immunity, Mucosal; Intestinal Diseases - immunology; Intestinal Diseases - microbiology; Intestinal Mucosa - immunology; Intestinal Mucosa - microbiology; Lymphocytes - immunology
• ISSN: 0372-9311

Topicality of interrelation between intestine infections, inflammation diseases of intestine and autoimmune processes is widely discussed in scientific literature of recent years. Thereby a review of literature on the designated aspect of the problem is dedicated to the analysis of interconnection between structural-functional features of lymphoid apparatus of intestine and its ability to react to antigen load from both commensal and pathogenic intestine microflora. During description of structure and functions of lymphoid formation of intestine a particular attention is paid to difference of subpopulation characteristics of lymphocytes and antigen-presenting cells composing intra-epithelial lymphocytes, elements ofimmune system lamina propria, Peyer's patches, mesenteric lymphatic nodes. The role of normal microflora and infectious agents in trigger mechanisms of reaction of immunocompetent cells is underscored; key aspects of cellular-molecular mechanisms of mucous membrane immune system functions are discussed.