Dental stem cells: dentinogenic, osteogenic, and neurogenic differentiation and its clinical cell based therapies

Each year approximately $400 billion is spent treating Americans suffering some type of tissue loss or end-stage organ failure. This includes millions of dental and oral craniofacial procedure, ranging from tooth restorations to major reconstruction of facial soft and mineralized tissue. Recently, a...

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Bibliographic Details
Published inIndian journal of dental research : official publication of Indian Society for Dental Research Vol. 23; no. 3; p. 393
Main Authors Brar, Gurlal Singh, Toor, Ravi Sher Singh
Format Journal Article
LanguageEnglish
Published India 01.05.2012
Subjects
Cell Culture Techniques
Dental Pulp - cytology
Dentinogenesis - physiology
Humans
Neurogenesis - physiology
Osteogenesis - physiology
Regenerative Medicine
Stem Cell Transplantation
Stem Cells - classification
Stem Cells - physiology
Tissue Engineering
Tooth, Deciduous - cytology
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Summary:Each year approximately $400 billion is spent treating Americans suffering some type of tissue loss or end-stage organ failure. This includes millions of dental and oral craniofacial procedure, ranging from tooth restorations to major reconstruction of facial soft and mineralized tissue. Recently, a population of putative post-natal stem cells in human dental pulp (DPSCs) has been identified within the "cell- rich zone" of dental pulp. The other type of stem cells from human exfoliated deciduous teeth (SHED) was identified to be a population of highly proliferative, clonogenic cells. Dental Pulp Stem Cells (DPSCs) can not only be derived from a very accessible tissue resource like SHED but are also capable of providing enough cells for potential cell-based therapies.
ISSN:1998-3603