Role of plasminogen/plasmin in functional activity of blood cells

The article deals with the data concerning structural peculiarities of plasminogen/plasmin molecule, which define the specificity of intermolecular interactions and provide the variety of its biological functions. The main principles of the modern classification of plasminogen receptors and factors,...

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Bibliographic Details
Published inUkrains'kyi biokhimichnyi zhurnal (1999 ) Vol. 84; no. 4; p. 5
Main Authors Zhernosekov, D D, Iusova, E I, Grinenko, T V
Format Journal Article
LanguageRussian
Published Ukraine 01.07.2012
Subjects
Apoptosis
Atherosclerosis - metabolism
Blood Platelets - cytology
Blood Platelets - metabolism
Endothelial Cells - cytology
Endothelial Cells - metabolism
Extracellular Matrix - metabolism
Fibrin - metabolism
Fibrinolysin - metabolism
Humans
Inflammation - metabolism
Macrophages - cytology
Macrophages - metabolism
Monocytes - cytology
Monocytes - metabolism
Plasminogen - metabolism
Platelet Aggregation - physiology
Receptors, Cell Surface - metabolism
Signal Transduction - physiology
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Summary:The article deals with the data concerning structural peculiarities of plasminogen/plasmin molecule, which define the specificity of intermolecular interactions and provide the variety of its biological functions. The main principles of the modern classification of plasminogen receptors and factors, which modulate their expression, have been presented. We have considered the mechanisms regulating both plasmin formation and activity on the surface of cells, fibrin and proteins of extracellular matrix. The data of previous investigators and our own results, concerning the influence of plasminogen/plasmin on platelet aggregation induced by different agonists, have been summarized. The participation of plasminogen/plasmin in atherogenesis and angiogenesis mediated by endotheliocyte receptors has been discussed. Special attention was given to plasminogen/plasmin proinflammatory function, which is realized by regulatory processes of activation, secretion, migration and apoptosis of monocytes and macrophages.