A case of chromomycosis treated by surgical therapy combined with preceded oral administration of terbinafine to reduce the size of the lesion

Chromomycosis is a chronic fungal disease of the skin and subcutaneous tissues caused by a group of dematiaceous black fungi. Small lesions can be removed with excision, but other cases are difficult to treat. We report a case of chromomycosis caused by Fonsecaea pedrosoi (F. pedrosoi). The case inv...

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Bibliographic Details
Published inThe Tokai journal of experimental and clinical medicine Vol. 37; no. 1; p. 6
Main Authors Tamura, Kana, Matsuyama, Takashi, Yahagi, Eiichiro, Kojima, Tomoko, Akasaka, Emiko, Kondo, Akio, Ikoma, Norihiro, Mabuchi, Tomotaka, Tamiya, Shiho, Ozawa, Akira, Mochizuki, Takashi
Format Journal Article
LanguageEnglish
Published Japan 20.04.2012
Subjects
Aged
Antifungal Agents - administration & dosage
Antifungal Agents - therapeutic use
Ascomycota - isolation & purification
Chromoblastomycosis - drug therapy
Chromoblastomycosis - microbiology
Chromoblastomycosis - surgery
Combined Modality Therapy
Humans
Male
Naphthalenes - administration & dosage
Naphthalenes - therapeutic use
Treatment Outcome
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Summary:Chromomycosis is a chronic fungal disease of the skin and subcutaneous tissues caused by a group of dematiaceous black fungi. Small lesions can be removed with excision, but other cases are difficult to treat. We report a case of chromomycosis caused by Fonsecaea pedrosoi (F. pedrosoi). The case involved a 74-year-old man, who had noted a lesion on the back of the right thigh, that was gradually enlarging and reaching up to 30 cm in diameter, in 20-years. From microscopic examination, sclerotic cells were seen. We diagnosed this case as chromomycosis caused by F. pedrosoi on mycological examination. The patient was initially treated with oral terbinafine (250 mg/day) as the lesion was very large. After the 18 months treatment, the size of the lesion reduced to 1 cm, then the remaining lesion was excised.
ISSN:2185-2243