Evaluation of the relative efficacy of copolymerized polylactic-polyglycolic acids alone and in conjunction with polyglactin 910 membrane in the treatment of human periodontal infrabony defects: a clinical and radiological study

• Published in: Indian journal of dental research : official publication of Indian Society for Dental Research Vol. 22; no. 1; p. 83
• Main Authors: Chhabra, Vipin, Gill, Amarjit Singh, Sikri, Poonam, Bhaskar, Nandini
• Format: Journal Article
• Language: English
• Published: India 01.01.2011
• Subjects: Absorbable Implants; Alveolar Bone Loss - complications; Alveolar Bone Loss - diagnostic imaging; Alveolar Bone Loss - surgery; Biocompatible Materials - therapeutic use; Bone Regeneration - drug effects; Bone Substitutes - therapeutic use; Guided Tissue Regeneration, Periodontal - methods; Humans; Lactic Acid - therapeutic use; Membranes, Artificial; Periodontal Diseases - complications; Periodontal Diseases - diagnostic imaging; Periodontal Diseases - surgery; Polyglactin 910 - therapeutic use; Polyglycolic Acid - therapeutic use; Radiography; Treatment Outcome
• ISSN: 1998-3603

Absorbable synthetic biopolymers have been used as bone filler in Periodontology, proving effective stimulants to bone regeneration. Copolymerized polylactic and polyglycolic acid is used as a bone filler and polyglactin 910 as a guided tissue regeneration (GTR) membrane to achieve regeneration in periodontal infrabony defects. Forty patients with two- or three-walled infrabony defects were selected and randomly divided into two groups. Group A included patients treated with polylactic-polyglycolic acids 50:50 (Fisiograft ,Ghimsa SPA,Via Fucini, Italy) alone and Group B included patients treated with polylactic-polyglycolic acids (PLA-PGA)50:50 in conjunction with polyglactin acid 910 (Vicryl Mesh Johnson&Johnson , U.S.A ). Evaluation of clinical parameters probing depth and attachment level and radiographs was done preoperatively and 12 and 24 weeks postoperatively. Both the groups showed statistically significant mean reduction in probing depth and gain in clinical attachment level and linear bone fill. Within the limit of this study, both the treatment modalities are beneficial for the treatment of infrabony defects.