Expression and clinical significance of metastasis-related tumor markers in colorectal cancer

• Published in: Ai zheng = Aizheng = Chinese journal of cancer Vol. 28; no. 9; p. 950
• Main Authors: Wan, Xiang-Bin, Pan, Zhi-Zhong, Ren, Ying-kun, Ding, Pei-Rong, Chen, Gong, Wan, De-Sen
• Format: Journal Article
• Language: Chinese
• Published: China 01.09.2009
• Subjects: Adult; Aged; Biomarkers, Tumor - metabolism; Colonic Neoplasms - metabolism; Colonic Neoplasms - pathology; Cyclooxygenase 2 - metabolism; Epidermal Growth Factor - metabolism; Female; Follow-Up Studies; Humans; Hyaluronan Receptors - metabolism; Male; Matrix Metalloproteinase 2 - metabolism; Middle Aged; Neoplasm Metastasis; Neoplasm Recurrence, Local; Neoplasm Staging; Receptor, Epidermal Growth Factor - metabolism; Rectal Neoplasms - metabolism; Rectal Neoplasms - pathology; Survival Rate; Vascular Endothelial Growth Factor A - metabolism; Young Adult

Besides current clinicopathologic staging system extensively used in clinic, more information of molecular staging is need for more accurate staging of colorectal cancer (CRC). This study was to evaluate the prognostic value of metastasis-related tumor markers in CRC. The expression of CD44v6, matrix matalloproteinase-2 (MMP-2), cyclooxygenase-2 (COX-2), epidermal growth factor (EGF), epidermal growth factor receptor (EGFR) and vascular epidermal growth factor (VEGF) in a tissue microarray containing 95 specimens of CRC were detected by immunohistochemistry (IHC). The correlations of these tumor markers to the prognosis of CRC patients were analyzed. In patients with Dukes' A/B disease, the 5-year recurrence rates were significantly higher in CD44v6-, EGF-and EGFR-positive groups than in negative groups (30.9% vs. 8.3%,P=0.045; 38.1% vs. 8.8%, P=0.022; 27.5% vs. 11.8%, P=0.047, respectively). In patients with Dukes' C disease, the 5-year recurrence rates were significantly higher in MMP-2-, COX-2-and VEGF-pos