Effect of a single emotional-pain stress on the basic carboxypeptidases activity in the rat brain regions and adrenals

Effect of a single emotional-algesic stress on the carboxypeptidase H and PMSF-inhibited carboxypeptidase activities (phenylmethylsulphonilfluoride-inhibited carboxypeptidase) taking part in the final stage of formation of biologically active neuropeptides from precursors, was studied. Activity of t...

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Bibliographic Details
Published inUkrains'kyi biokhimichnyi zhurnal (1999 ) Vol. 76; no. 3; p. 68
Main Authors Vernigora, A N, Bardinova, Zh S, Smetanin, V A, Gengin, M T
Format Journal Article
LanguageRussian
Published Ukraine 01.05.2004
Subjects
Adrenal Glands - enzymology
Animals
Brain - enzymology
Carboxypeptidase H - antagonists & inhibitors
Carboxypeptidase H - metabolism
Enzyme Inhibitors - pharmacology
Male
Neuropeptides - metabolism
Pain - complications
Pain - enzymology
Phenylmethylsulfonyl Fluoride - pharmacology
Rats
Stress, Psychological - complications
Stress, Psychological - enzymology
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Summary:Effect of a single emotional-algesic stress on the carboxypeptidase H and PMSF-inhibited carboxypeptidase activities (phenylmethylsulphonilfluoride-inhibited carboxypeptidase) taking part in the final stage of formation of biologically active neuropeptides from precursors, was studied. Activity of the enzymes depended on duration of the stress and time after the stress in pituitary and adrenal glands. Differences in changes of carboxypeptidase H and PMSF-inhibited carboxypeptidase activities was found, especially in adrenals. The role of enzymes in emotional-algesic stress development and in metabolism of regulatory peptides by the stress was discussed.