Modification of recombinant proteins by covalent polysialation illustrated with the example of human insulin

Methods of selective and nonselective covalent immobilization of genetically engineered proteins on molecules of natural polysialic acid are described by the example of human insulin. Such modification increases insulin lifetime in vivo.

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Bibliographic Details
Published inBioorganicheskaia khimiia Vol. 35; no. 2; p. 274
Main Authors Bezuglov, V V, Gretskaia, N M, Bobrov, M Iu, Akimov, M G, Fomina-Ageeva, E V, Zinchenko, G N, Bairamashvili, D I, Miroshnikov, A I
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.03.2009
Subjects
Humans
Insulin - chemistry
Recombinant Proteins - chemistry
Sialic Acids - chemistry
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Summary:Methods of selective and nonselective covalent immobilization of genetically engineered proteins on molecules of natural polysialic acid are described by the example of human insulin. Such modification increases insulin lifetime in vivo.
ISSN:0132-3423