Development and assessment of a new test for verification of tests for HIV-infection markers

The OOO "Research-and-Production Association "Diagnostic Systems" has developed a "DC-EIA-HIV-AT/AG-SPECTRUM" screening enzyme immunoassay system designed to detect separately antibodies to certain HIV-1 and HIV-2 proteins, as well as antigen p24. The determination of antibo...

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Bibliographic Details
Published inKlinicheskaia laboratornaia diagnostika no. 3; p. 40
Main Authors Baranova, E N, Sharipova, I N, Kudriavtseva, E N, Lobanova, O A, Puzyrev, V F, Riabinina, S A, Burkov, A N, Obriadina, A P, Ulanova, T I
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.03.2008
Subjects
Antigens, Viral - chemistry
Antigens, Viral - immunology
Biomarkers - blood
Epitopes - chemistry
Epitopes - immunology
HIV Antibodies - blood
HIV Antibodies - immunology
HIV Infections - blood
HIV Infections - immunology
HIV-1 - chemistry
HIV-1 - immunology
HIV-2 - chemistry
HIV-2 - immunology
Humans
Immunoenzyme Techniques - methods
Immunoenzyme Techniques - standards
Recombinant Proteins - chemistry
Recombinant Proteins - immunology
Sensitivity and Specificity
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Summary:The OOO "Research-and-Production Association "Diagnostic Systems" has developed a "DC-EIA-HIV-AT/AG-SPECTRUM" screening enzyme immunoassay system designed to detect separately antibodies to certain HIV-1 and HIV-2 proteins, as well as antigen p24. The determination of antibodies of all classes and the marker of early-stage infection antigen p24 with a high (5 pg/ml) sensitivity substantially reduces the number of void results obtained in the use of immunoblots. The developed "DC-EIA-HIV-AT/AG-SPECTRUM" plate system is an effective tool to support positive screening results and may be used at the final stage of laboratory diagnosis of HIV infection.
ISSN:0869-2084