Functions of heat shock proteins in the system of adaptive immunity. Construction of vaccines

One of the most important aspects of heat shock proteins (HSP) functioning, namely their role in reactions of innate and adaptive immunity, was reviewed in the article. Mechanisms of involvement of HSP in processing and presentation of antigens to T-lymphocytes were described. Principles of construc...

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Bibliographic Details
Published inŽurnal mikrobiologii, ėpidemiologii i immunobiologii no. 6; p. 108
Main Authors Sveshnikov, P G, Malaĭtsev, V V, Kiselev, V I
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.11.2007
Subjects
Animals
Antigen Presentation
Antigens, Bacterial - immunology
Autoimmunity
Bacterial Infections - immunology
Bacterial Proteins - immunology
Bacterial Vaccines - adverse effects
Heat-Shock Proteins - immunology
Humans
Hypersensitivity - etiology
Immunity, Active
Immunity, Innate
T-Lymphocytes - immunology
Vaccines, Synthetic - adverse effects
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Summary:One of the most important aspects of heat shock proteins (HSP) functioning, namely their role in reactions of innate and adaptive immunity, was reviewed in the article. Mechanisms of involvement of HSP in processing and presentation of antigens to T-lymphocytes were described. Principles of construction of prophylactic and therapeutic vaccines on the basis of HSP were set out. Assessment of range of indications for their use and possible risks related with inductive action of vaccines on the development of immunopathologic processes was a specially discussed topic.
ISSN:0372-9311