The dynamics of the humoral immune response to mycobacterial antigens in mice

The main regularities of humoral immune response to mycobacterial antigens have been studied in experiments on BALB/c mice immunized with live and thermoinactivated Mycobacterium tuberculosis, var. bovis. As shown in this study, the maximum level of serum antibodies to mycobacterial antigen is achie...

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Bibliographic Details
Published inŽurnal mikrobiologii, ėpidemiologii i immunobiologii no. 10; p. 61
Main Authors Liashchenko, K P, Bobrovnik, S A, Komissarenko, S V
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.10.1991
Subjects
Animals
Antibodies, Bacterial - blood
Antibody Formation - immunology
Antibody Specificity - immunology
Antigen-Antibody Complex - blood
Antigens, Bacterial - immunology
BCG Vaccine - immunology
Dose-Response Relationship, Immunologic
Immunization
Immunization, Secondary
Mice
Mice, Inbred BALB C
Mycobacterium bovis - immunology
Time Factors
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Summary:The main regularities of humoral immune response to mycobacterial antigens have been studied in experiments on BALB/c mice immunized with live and thermoinactivated Mycobacterium tuberculosis, var. bovis. As shown in this study, the maximum level of serum antibodies to mycobacterial antigen is achieved in two weeks after immunization irrespective of the dose and viability or mycobacteria, then follows a decrease in the antibody level. The absence of uniformity in the dependence of primary immune response and the formation of immunological memory on the dose and viability of mycobacteria has been demonstrated.
ISSN:0372-9311