Mechanical forces and human saphenous veins: coronary artery bypass graft implications

Vascular endothelial cells are exposed to a variety of in vivo mechanical forces, specifically, shear stress for the blood flow, tensile stress from the compliance of the vessel wall and the hydrostatic pressure from containment of blood within inside the vasculature. Many authors studied hemodynami...

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Published inRevista brasileira de cirurgia cardiovascular : orgao oficial da Sociedade Brasileira de Cirurgia Cardiovascular Vol. 22; no. 1; p. 87
Main Authors Tineli, Rafael Angelo, Viaro, Fernanda, Dalio, Marcelo Bellini, Reis, Graziela Saraiva, Basseto, Solange, Vicente, Walter Villela de Andrade, Rodrigues, Alfredo José, Evora, Paulo Roberto Barbosa
Format Journal Article
LanguageEnglish
Published Brazil 01.01.2007
Subjects
Animals
Coronary Artery Bypass
Endothelial Cells - physiology
Endothelium, Vascular - physiology
Humans
Hydrostatic Pressure
Saphenous Vein - physiology
Saphenous Vein - transplantation
Shear Strength
Stress, Mechanical
Tissue and Organ Harvesting - methods
Vascular Patency
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Summary:Vascular endothelial cells are exposed to a variety of in vivo mechanical forces, specifically, shear stress for the blood flow, tensile stress from the compliance of the vessel wall and the hydrostatic pressure from containment of blood within inside the vasculature. Many authors studied hemodynamic, functional and morphological human saphenous veins alterations caused by these different forces with conflictant results. This review text was motivated with the specific aim of analyze literature data and some experimental data carried out in our laboratory. The adopted review subjects were: 1) Endothelial responses and gene regulation to shear stress; 2) Effects of the hydrostatic pressure in the endothelial cell morphology, gene expression of the endothelial cellular surface and proliferation of endothelial cells; 3) Effects of the traction on the human saphenous vein endothelium.