Comparison of the characteristics in recurrence and metastasis between bronchioloalveolar carcinoma and other lung adenocarcinomas

• Published in: Ai zheng = Aizheng = Chinese journal of cancer Vol. 26; no. 7; p. 785
• Main Authors: Zhong, Xiao-Jun, Li, Dao-Tang, Li, Xiu-Ling, Mu, Dian-Bin, Zhang, Xing-Guo, Luo, Jing-Yu
• Format: Journal Article
• Language: Chinese
• Published: China 01.07.2007
• Subjects: Adenocarcinoma - metabolism; Adenocarcinoma - pathology; Adenocarcinoma - secondary; Adenocarcinoma - surgery; Adenocarcinoma, Bronchiolo-Alveolar - metabolism; Adenocarcinoma, Bronchiolo-Alveolar - pathology; Adenocarcinoma, Bronchiolo-Alveolar - secondary; Adenocarcinoma, Bronchiolo-Alveolar - surgery; Bone Neoplasms - secondary; Brain Neoplasms - secondary; Cadherins - metabolism; Collagen Type IV - metabolism; Female; Follow-Up Studies; Humans; Lung Neoplasms - metabolism; Lung Neoplasms - pathology; Lung Neoplasms - surgery; Male; Matrix Metalloproteinase 9 - metabolism; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Survival Rate; Tissue Inhibitor of Metalloproteinase-1 - metabolism; Vascular Endothelial Growth Factor Receptor-2 - metabolism

The histological definition of bronchioloalveolar carcinoma (BAC) has been changed recently by the revised World Health Organization (WHO) classification. Although bronchioloalveolar carcinoma is a subtype of lung adenocarcinoma, its biological features are better than those of other lung adenocarcinomas. This study was to analyze differences in metastatic activity between bronchioloalveolar carcinoma and other lung adenocarcinomas. The expression of E-Cadherin, Collagen IV, vascular endothelial growth factor receptor-2 (VEGFR-2), matrix metalloproteinase-9 (MMP-9), and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) in 28 specimens of stage I bronchioloalveolar carcinoma confirmed pathologically and 40 specimens of other stage I lung adenocarcinomas were detected by immunohistochemistry. Their correlations to tumor recurrence and metastasis were analyzed. The 5-year survival rate was significantly higher in ths patients with bronchioloalveolar carcinoma than in the patients with other lung adenocarci