Comparison of the characteristics in recurrence and metastasis between bronchioloalveolar carcinoma and other lung adenocarcinomas

The histological definition of bronchioloalveolar carcinoma (BAC) has been changed recently by the revised World Health Organization (WHO) classification. Although bronchioloalveolar carcinoma is a subtype of lung adenocarcinoma, its biological features are better than those of other lung adenocarci...

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Bibliographic Details
Published inAi zheng = Aizheng = Chinese journal of cancer Vol. 26; no. 7; p. 785
Main Authors Zhong, Xiao-Jun, Li, Dao-Tang, Li, Xiu-Ling, Mu, Dian-Bin, Zhang, Xing-Guo, Luo, Jing-Yu
Format Journal Article
LanguageChinese
Published China 01.07.2007
Subjects
Adenocarcinoma - metabolism
Adenocarcinoma - pathology
Adenocarcinoma - secondary
Adenocarcinoma - surgery
Adenocarcinoma, Bronchiolo-Alveolar - metabolism
Adenocarcinoma, Bronchiolo-Alveolar - pathology
Adenocarcinoma, Bronchiolo-Alveolar - secondary
Adenocarcinoma, Bronchiolo-Alveolar - surgery
Bone Neoplasms - secondary
Brain Neoplasms - secondary
Cadherins - metabolism
Collagen Type IV - metabolism
Female
Follow-Up Studies
Humans
Lung Neoplasms - metabolism
Lung Neoplasms - pathology
Lung Neoplasms - surgery
Male
Matrix Metalloproteinase 9 - metabolism
Middle Aged
Neoplasm Recurrence, Local
Neoplasm Staging
Survival Rate
Tissue Inhibitor of Metalloproteinase-1 - metabolism
Vascular Endothelial Growth Factor Receptor-2 - metabolism
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Summary:The histological definition of bronchioloalveolar carcinoma (BAC) has been changed recently by the revised World Health Organization (WHO) classification. Although bronchioloalveolar carcinoma is a subtype of lung adenocarcinoma, its biological features are better than those of other lung adenocarcinomas. This study was to analyze differences in metastatic activity between bronchioloalveolar carcinoma and other lung adenocarcinomas. The expression of E-Cadherin, Collagen IV, vascular endothelial growth factor receptor-2 (VEGFR-2), matrix metalloproteinase-9 (MMP-9), and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) in 28 specimens of stage I bronchioloalveolar carcinoma confirmed pathologically and 40 specimens of other stage I lung adenocarcinomas were detected by immunohistochemistry. Their correlations to tumor recurrence and metastasis were analyzed. The 5-year survival rate was significantly higher in ths patients with bronchioloalveolar carcinoma than in the patients with other lung adenocarci