Synthetic fragments of the NS1 protein of the tick-borne encephalitis virus exhibiting a protective effect
Potentially immunoactive regions of the NS1 nonstructural protein of the tick-borne encephalitis virus that can stimulate the antibody formation in vivo and protect animals from this disease were chosen on the basis of theoretical calculations. Eleven 16- to 27-aa peptides containing the chosen regi...
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Published in | Bioorganicheskaia khimiia Vol. 33; no. 2; p. 229 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | Russian |
Published |
Russia (Federation)
01.03.2007
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Subjects | |
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Abstract | Potentially immunoactive regions of the NS1 nonstructural protein of the tick-borne encephalitis virus that can stimulate the antibody formation in vivo and protect animals from this disease were chosen on the basis of theoretical calculations. Eleven 16- to 27-aa peptides containing the chosen regions were synthesized. The ability of the free peptides (without any high-molecular-mass carrier) to stimulate the production of antipeptide antibodies in mice of three lines and ensure the formation of protective immunity was studied. Most of these peptides were shown to exhibit the immunogenic activity in a free state. Five fragments that can protect mice from the infection by a lethal dose of tick-borne encephalitis virus were found. |
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AbstractList | Potentially immunoactive regions of the NS1 nonstructural protein of the tick-borne encephalitis virus that can stimulate the antibody formation in vivo and protect animals from this disease were chosen on the basis of theoretical calculations. Eleven 16- to 27-aa peptides containing the chosen regions were synthesized. The ability of the free peptides (without any high-molecular-mass carrier) to stimulate the production of antipeptide antibodies in mice of three lines and ensure the formation of protective immunity was studied. Most of these peptides were shown to exhibit the immunogenic activity in a free state. Five fragments that can protect mice from the infection by a lethal dose of tick-borne encephalitis virus were found. |
Author | Titova, M A Oboznaia, M B Volkova, T D Ozherelkov, S V Timofeev, A V Vol'pina, O M Koroev, D O Vorovich, M F Filatova, M P |
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SubjectTerms | Amino Acid Sequence Animals Antibodies, Viral - blood Encephalitis, Tick-Borne - prevention & control Immunization Mice Mice, Inbred Strains Molecular Sequence Data Peptides - chemistry Peptides - immunology Peptides - therapeutic use Viral Nonstructural Proteins - chemistry Viral Nonstructural Proteins - immunology Viral Nonstructural Proteins - therapeutic use |
Title | Synthetic fragments of the NS1 protein of the tick-borne encephalitis virus exhibiting a protective effect |
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