Irradiation-induced uterine malignant mixed müllerian tumor

To report a case of a patient with cervical squamous cell carcinoma stage IIIB who was diagnosed with malignant mixed müllerian tumor (MMMT) 5 years after radiotherapy. A 57-year-old female patient with cervical squamous cell carcinoma FIGO stage IIIB received pelvic irradiation for her disease. Aft...

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Bibliographic Details
Published inTaiwanese journal of obstetrics & gynecology Vol. 45; no. 4; p. 353
Main Authors Huang, Ying-Ti, Huang, Kuan-Gen, Ueng, Shir-Hwa, Shaw, Sheng-Wen
Format Journal Article
LanguageEnglish
Published China (Republic : 1949- ) 01.12.2006
Subjects
Adenocarcinoma - diagnosis
Adenocarcinoma - etiology
Carcinoma, Squamous Cell - radiotherapy
Fatal Outcome
Female
Humans
Middle Aged
Mixed Tumor, Mullerian - diagnosis
Mixed Tumor, Mullerian - etiology
Neoplasm Recurrence, Local
Neoplasms, Radiation-Induced - diagnosis
Radiotherapy - adverse effects
Uterine Cervical Neoplasms - radiotherapy
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Summary:To report a case of a patient with cervical squamous cell carcinoma stage IIIB who was diagnosed with malignant mixed müllerian tumor (MMMT) 5 years after radiotherapy. A 57-year-old female patient with cervical squamous cell carcinoma FIGO stage IIIB received pelvic irradiation for her disease. After radiotherapy, she was followed-up every 6 months. At 60 months, Papanicolaou smear revealed abnormal cancer cells and secondary MMMT was diagnosed. The patient underwent surgical treatment followed by chemotherapy. However, the cancer recurred 8 months after surgery and the patient died 1 month later. Patients with cervical cancer administered irradiation many years previously remain at high risk of secondary malignancies. In these cases, long-term follow-up with extreme caution is mandatory. For patients with any types of symptoms, aggressive and immediate investigation is suggested in order to detect possible occult malignancies.
ISSN:1875-6263