Hormonal replacement therapy and selective estrogen receptor modulators in prevention of cardiovascular disease

Postmenopausal women are at higher risk of cardiovascular disease because of increased prevalence of major coronary artery disease risk factors. The protective activity on cardiovascular system of estrogen was postulated. The data from many studies indicate favourable effect of estrogen replacement...

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Bibliographic Details
Published inWiadomości lekarskie (1960) Vol. 59; no. 5-6; p. 377
Main Authors Kozakiewicz, Krystyna, Wycisk, Anna
Format Journal Article
LanguagePolish
Published Poland 2006
Subjects
Cardiovascular Diseases - chemically induced
Cardiovascular Diseases - prevention & control
Estrogen Antagonists - therapeutic use
Estrogens - adverse effects
Estrogens - therapeutic use
Female
Hormone Replacement Therapy - adverse effects
Humans
Longitudinal Studies
Raloxifene Hydrochloride - administration & dosage
Randomized Controlled Trials as Topic
Receptors, Estrogen - drug effects
Selective Estrogen Receptor Modulators - adverse effects
Selective Estrogen Receptor Modulators - therapeutic use
Tamoxifen - administration & dosage
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Summary:Postmenopausal women are at higher risk of cardiovascular disease because of increased prevalence of major coronary artery disease risk factors. The protective activity on cardiovascular system of estrogen was postulated. The data from many studies indicate favourable effect of estrogen replacement therapy. However prospective, randomized clinical trials have not proved protective influence of hormonal replacement therapy (HRT) on cardiovascular system. Moreover it was found to increased the risk of cardiovascular disease events. This article presents mechanism of estrogens activity and results of major clinical trials concerning hormonal replacement therapy. Activity of selective estrogen receptor modulators (SERMs) was also described.
ISSN:0043-5147