Correlation between the expression of HER-2/neu, nm23 protein and local invasion and lymph node metastasis of human LSCC

• Published in: Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology Vol. 20; no. 6; p. 259
• Main Authors: Li, Qin, Chen, Yanlin, Kong, Ping, Ming, Wei, Ma, Yanyan, Yang, Zhaoke, Du, Yinghua, Zhang, Daliang
• Format: Journal Article
• Language: Chinese
• Published: China 01.03.2006
• Subjects: Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Carcinoma, Squamous Cell - metabolism; Carcinoma, Squamous Cell - pathology; Female; Humans; Laryngeal Neoplasms - metabolism; Laryngeal Neoplasms - pathology; Lymph Nodes - pathology; Male; Middle Aged; Neoplasm Metastasis; NM23 Nucleoside Diphosphate Kinases - metabolism; Receptor, ErbB-2 - metabolism

To explore the relationship between the expressions of HER-2/neu, nm23 protein and local invasion and lymp node metastasis of LSCC. The expression of HER-2/neu, nm23 protein was detected by immunohistochemical technique in 56 patients with human LSCC. The positive expression rate of HER-2/neu protein in LSCC was not correlated with histological grade (P > 0.05). There was a significant relationship between the expression of HER-2/neu and the clinical stages, lymph node metastasis (P < 0.05, P < 0.01). The positive expression rate of nm23 protein was significantly higher in the group without lymph node metastasis than those with lymph node metastasis (P < 0.01). The negative correlation was found between the nm23 expression and lymph node metastasis of LSCC. Furthermore, the negative correlation was found between the positive expression of HER-2/neu protein and the positive expression of nm23 protein in the group with lymph node metastasis. The abnormal expression of HER-2/neu, nm23 protein play an important r