Beneficial effects of metoprolol on perioperative cardiac function of elderly esophageal cancer patients

• Published in: Ai zheng = Aizheng = Chinese journal of cancer Vol. 25; no. 5; p. 609
• Main Authors: Lai, Ren-Chun, Xu, Mei-Xi, Huang, Wen-Qi, Wang, Xu-Dong, Zeng, Wei-An, Lin, Wen-Qian
• Format: Journal Article
• Language: Chinese
• Published: China 01.05.2006
• Subjects: Aged; Atrial Fibrillation - prevention & control; Blood Pressure; Cardiotonic Agents - therapeutic use; Esophageal Neoplasms - physiopathology; Esophageal Neoplasms - surgery; Esophagectomy; Female; Heart Rate; Hemodynamics; Humans; Intraoperative Complications - prevention & control; Male; Metoprolol - therapeutic use; Myocardial Ischemia - prevention & control; Perioperative Care; Tachycardia - etiology; Troponin T - blood

The elderly esophageal cancer patients undergoing esophagectomy are increasing now. How to protect their cardiac functions and reduce perioperative mortality and morbidity of cardiac events is an urgent problem to be solved. Prophylactic beta-blockers have been recently applied during surgery. This study was to evaluate the beneficial effects of metoprolol on perioperative cardiac function of elderly esophageal cancer patients. The esophageal cancer patients, no less than 65 years old, scheduled for elective esophagectomy were enrolled, and randomized into metoprolol group and control group. The patients of metoprolol group received metoprolol to control heart rate from anesthesia induction to 72 h after operation. Perioperative hemodynamic data were recorded at time points of baseline, drug administration, 2 min after induction, intubation, 4 min after intubation, incision, thoracic exposure, 60 min after incision, 10 min before the completion of operation, the completion of operation, extubation, and 15 min