Assessment of free radical formation process in rats with different audiogenic seizure susceptibility by means of biochemiluminiscent methods

Complex investigation of free radical process intensity by means of spontaneous, Fe(2+)- and H2O2-induced, luminol dependent biochemiluminescent methods was performed. The increased formation of reactive oxygen species and no change of hydroperoxide levels were found in brain of rats with high seizu...

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Bibliographic Details
Published inUkrains'kyi biokhimichnyi zhurnal (1999 ) Vol. 77; no. 4; p. 129
Main Author Popova, L D
Format Journal Article
LanguageUkrainian
Published Ukraine 01.07.2005
Subjects
Acoustic Stimulation
Animals
Brain - drug effects
Brain - metabolism
Brain - physiology
Ferrous Compounds - pharmacology
Free Radicals - metabolism
Hydrogen Peroxide - pharmacology
Lipid Peroxidation - drug effects
Luminescent Measurements
Rats
Rats, Wistar
Seizures - etiology
Seizures - physiopathology
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Summary:Complex investigation of free radical process intensity by means of spontaneous, Fe(2+)- and H2O2-induced, luminol dependent biochemiluminescent methods was performed. The increased formation of reactive oxygen species and no change of hydroperoxide levels were found in brain of rats with high seizure susceptibility.