Participation of cyclic nucleotides and phospholipidis in signal transduction of histamin receptor H3 of the gastric mucosa parietal cells in rats with experimental ulcer

The goal of the work was to evaluate plasma membrane phospholipid composition in rat gastric parietal cells under the histamine H3 receptor activation. The content of cyclic nucleotides was also studied. It was shown that H3-receptor agonist (R)-alpha-methylhistamine increases the phosphatidylcholin...

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Published inUkrains'kyi biokhimichnyi zhurnal (1999 ) Vol. 77; no. 2; p. 118
Main Authors Chaĭka, V O, Havrysh, L I, Khil'ko, T D, Ostapchenko, L I
Format Journal Article
LanguageUkrainian
Published Ukraine 01.03.2005
Subjects
Animals
Disease Models, Animal
Gastric Mucosa - cytology
Gastric Mucosa - drug effects
Gastric Mucosa - metabolism
Histamine Agonists - pharmacology
Male
Methylhistamines - pharmacology
Nucleotides, Cyclic - metabolism
Parietal Cells, Gastric - drug effects
Parietal Cells, Gastric - metabolism
Phospholipids - metabolism
Rats
Rats, Wistar
Receptors, Histamine H3 - metabolism
Signal Transduction - drug effects
Stomach Ulcer - metabolism
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Summary:The goal of the work was to evaluate plasma membrane phospholipid composition in rat gastric parietal cells under the histamine H3 receptor activation. The content of cyclic nucleotides was also studied. It was shown that H3-receptor agonist (R)-alpha-methylhistamine increases the phosphatidylcholine (PC) and phosphatidylethanolamine (PE) level and decreases the phoshatidylinositole level in plasma membrane of rat gastric parietal cells and leads to attenuation of the cGMP production and enhancement of the cAMP production under the experimental stress--the induced stomach ulcer formation. The histamine H3-receptor antagonist, thioperamide, insignificantly increases the PC and PE level and increases the phoshatidylinositole level in the plasma membrane of rat gastric parietal cells and leads to cAMP production attenuation, and cGMP contents decreases in the above-stated cells. Thus it was shown that histamine H3 receptor activation causes different effects on polyphosphoinositide and adenylatcyclase cascades in parietal cells under stomach ulcer conditions.