Antibacterial acitivity of the peptide complex isolated from the preparation of leukocytic interferon

• Published in: Žurnal mikrobiologii, ėpidemiologii i immunobiologii no. 5; p. 54
• Main Authors: Volkova, L V, Kosareva, P V, Popov, V F, Timasheva, O A
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 01.09.2005
• Subjects: Anti-Infective Agents - isolation & purification; Anti-Infective Agents - pharmacology; Antimicrobial Cationic Peptides - isolation & purification; Antimicrobial Cationic Peptides - pharmacology; Enterobacteriaceae - drug effects; Enterobacteriaceae - isolation & purification; Humans; Interferons - chemistry; Osmolar Concentration; Peptides - isolation & purification; Peptides - pharmacology; Staphylococcus aureus - drug effects; Staphylococcus aureus - isolation & purification; Urinary Tract Infections - microbiology
• ISSN: 0372-9311

A complex of low-molecular cationic peptides having an anti-bacterial effect with respect to Gram-positive and Gram-negative bacteria was isolated from the preparation of leukocytic interferon. The antibacterial action of the peptide complex was experimentally studied in vitro. The study revealed that the degree of the antibacterial activity of the peptide complex depended on the concentration of the bacterial culture under study, the ionic power of the incubation medium and did not depend on the presence of the products of bacterial vital activity in the growth medium. The antibacterial action of the peptide complex on the test cultures of Gram-positive and Gram-negative bacteria, as well as on the cultures of bacteria isolated from patients with infectious inflammatory diseases of the organs of the urinary system, was established. These results opened prospects for the development of fundamentally new antibacterial preparation on the basis of the peptide complex obtained in our studies.